Protein design method development

• HyperMPNN–A general strategy to design thermostable proteins learned from hyperthermophiles.

  Ertelt, M., Schlegel, P., Beining, M., Kaysser, L., Meiler, J. and Schoeder, C.T., 2024. bioRxiv.

• Self-supervised machine learning methods for protein design improve sampling but not the identification of high-fitness variants.

  Ertelt, M., Moretti, R., Meiler, J. and Schoeder, C.T., 2025. Science Advances, 11(7), p.eadr7338.

• Combining Rosetta sequence design with protein language model predictions using evolutionary scale modeling (ESM) as restraint.

  Ertelt, M., Meiler, J. and Schoeder, C.T., 2024. ACS synthetic biology, 13(4), pp.1085-1092.

• Combining machine learning with structure-based protein design to predict and engineer post-translational modifications of proteins.

  Ertelt, M., Mulligan, V.K., Maguire, J.B., Lyskov, S., Moretti, R., Schiffner, T., Meiler, J. and Schoeder, C.T., 2024. PLOS Computational Biology, 20(3), p.e1011939.

• Rosetta design with co-evolutionary information retains protein function.

  Schmitz, S., Ertelt, M., Merkl, R. and Meiler, J., 2021. PLoS Computational Biology, 17(1), p.e1008568.

Adeno-associated virus vector engineering

• Adeno‐associated virus serotype 2 capsid variants for improved liver‐directed gene therapy.

  Meumann, N., Cabanes‐Creus, M., Ertelt, M., Navarro, R.G., Lucifora, J., Yuan, Q., Nien‐Huber, K., Abdelrahman, A., Vu, X.K., Zhang, L. and Franke, A.C., 2023. Hepatology, 77(3), pp.802-815.

• Modifying immune responses to adeno-associated virus vectors by capsid engineering.

  Bentler, M., Hardet, R., Ertelt, M., Rudolf, D., Kaniowska, D., Schneider, A., Vondran, F.W., Schoeder, C.T., Delphin, M., Lucifora, J. and Ott, M., 2023. Molecular therapy Methods & clinical development, 30, pp.576-592.

CAR T cell engineering

• Integrating binding affinity and tonic signaling enables a rational CAR design for augmented T cell function.

  Barden, M., Elsenbroich, P.R., Haas, V., Ertelt, M., Pervan, P., Velas, L., Gergely, B., Szöőr, Á., Harrer, D.C., Bezler, V. and Holzinger, A., 2024. Journal for ImmunoTherapy of Cancer, 12(12), p.e010208.